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Some of these variants have been associated with the metabolism of alcohol and nicotine, while others involve receptors and other proteins associated with key neurotransmitters and molecules involved in all parts of the addiction cycle. Sex differences in reaction to addictive substances are not particular to humans.
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Many studies have shown that neurons that release dopamine are activated, either directly or indirectly, by all addictive substances, but particularly by stimulants such as cocaine, amphetamines, and nicotine Figure 2.
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Frontiers in Systems Neuroscience.
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However, over time, the neurons stopped firing in response to the drug and instead fired when they were exposed to the neutral stimulus associated with it.
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This stage of addiction involves a decrease in the function of the brain reward systems and an activation of stress neurotransmitters, such as CRF and dynorphin, in the extended amygdala. This stage of the addiction cycle is characterized by a disruption of executive function caused by a compromised prefrontal cortex.
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There may be variation in how people progress through the cycle and the intensity with which they experience each of the stages. The American Journal of Psychiatry.
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